EZSolution™ GDC-0449

A potent inhibitor of Smoothened (SMO), a key mediator of Hedgehog (Hh) signaling pathway. Inhibition of SMO renders the transcription factor GLI inactive, thus preventing the expression of genes that mediate the role of Hh on tumor growth.

Alternate Name/Synonyms: 2-Chloro-N-(4-chloro-3-(pyridine-2-yl)phenyl)-4-(methylsulfonyl)benzamide; HhAntag691

Appearance: Liquid

Appearance: A 10 mM solution in anhydrous DMSO

Appearance: 879085-55-9

Appearance: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₄Cl₂N₂O₃S

Molecular Weight: 421.3

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: N/A

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A Smoothened (Smo) antagonist

MDL Number: MFCD12407408

PubChem CID: 24776445

SMILES: CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl

InChi: InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24)

InChi Key: BPQMGSKTAYIVFO-UHFFFAOYSA-N

Category: Biochemicals