Human CellExp™ LAIR1 / CD305, Fc Tag, Mouse Recombinant
- Usually Shipped in 5 Working Days
- Storage Temperature:
- Shipping Conditions:
- Gel Pack
- Shelf Life:
- 12 months
Synonyms: LAIR1, CD305
Alternates names: LAIR1, CD305
Taglines: Negative regulator of NK cells, B cells and T cells
Country of Animal Origin: USA
NCBI Gene ID #.: 52855
NCBI Gene Symbol: Lair1
Gene Source: Mouse
Accession #: Q8BG84-1
Source: HEK 293 cells
Purity by SDS-PAGE #: >95%
Assay #2: N/A
Endotoxin Level: Less than 0.1 EU per μg by the LAL method.
Activity (Specifications/test method): N/A
Biological activity: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 40.6 kDa. The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Appearance: Lyophilized powder
Physical form description: Lyophilized protein
Reconstitution Instructions: Reconstitute in sterile deionized water to a desired concentration.
Background Information: Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell–mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.
Amino acid sequence: AA Gln 22 - Tyr 141
Handling: Centrifuge the vial prior to opening.