BioSim™ Golimumab (Human) ELISA Kit
- Usually Shipped in 5 Working Days
- 100 Assays
- Storage Conditions:
- Shipping Conditions:
- Gel Pack
- Shelf life:
- 12 months
Golimumab is a human immunoglobulin G1κ monoclonal antibody that is specific for pro-inflammatory cytokine, tumor necrosis factor-α (TNFα). In 2009, it was approved by the FDA for the treatment of rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis in adult patients. Elevated levels of TNF are found in the synovial fluid of rheumatoid arthritis, including juvenile idiopathic arthritis, psoriatic arthritis, and ankylosing spondylitis. Pathological inflammation and joint destruction are hallmarks of these diseases. Increased levels of TNF are also found in psoriasis (Ps) plaques. Golimumab binds to both the soluble and transmembrane bioactive forms of human TNF and prevents TNF from binding to its receptors and finally inhibits the biological activity of TNF. BioVision’s BioSim™ Golimumab ELISA kit has been developed for specific quantification of Golimumab concentration in human serum or plasma with high sensitivity and reproducibility.
Alternate Name: DIF, TNFA, TNFSF2, TNLG1F, TNF-alpha, TNF, CAS 476181-74-5
Tag Line: A Sandwich ELISA kit for the quantitative measurement of free Golimumab in human serum or plasma.
Detection Method: Absorbance (450 nm)
Sample Type: Human serum and plasma
Species Reactivity: Human
Applications: This ELISA kit is used for quantitative measurement of Golimumab in human serum and plasma
Features & Benefits: • Easy, convenient, sensitive and time-saving method to measure the level of Golimumab in human serum and plasma. •Detection range: 100 – 3000 ng/ml • Sensitivity: 100 ng/ml • Assay Precision: Intra-Assay: CV < 15%; Inter-Assay: CV < 15% (CV (%) = SD/mean X 100) • Recovery rate: 85 – 115% with normal human serum samples with known concentrations • Cross Reactivity: No significant cross-reactivity or interference with other proteins present in native human serum or other therapeutic immunoglobulins.