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EZSolution™ Dorsomorphin

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SKU:
26-2547
Availability:
Usually Shipped in 5 Working Days
Size:
5 mg
Storage Condition:
-20°C
Shipping Condition:
gel pack
Shelf Life:
12 months
€198.00
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Description

Cell-permeable. A potent, selective , reversible and ATP-competitive inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM in the presence of 5 µM ATP and no AMP). Does not affect the activity on several structurally related kinases including JAK3, PKA, PKCθ, SYK and ZAPK. Also inhibits bone morphogenic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). In addition, recently Dorsomorphin has shown to induce protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway.

Alternate Name/Synonyms: 6-[4-(2-Piperidin-1-yl)-ethoxy)-phenyl)]-3-pyridin-4-yl- pyrazolo[1,5-a]-pyrimidine; Compound C

Appearance: Liquid

Appearance: A 10 mM solution in anhydrous DMSO

Appearance: 866405-64-3

Appearance: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₂₅N₅O

Molecular Weight: 399.49

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: N/A

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: An AMP kinase inhibitor

MDL Number: MFCD08705402

PubChem CID: 11524144

SMILES: C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3

InChi: InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2

InChi Key: XHBVYDAKJHETMP-UHFFFAOYSA-N

Category: Biochemicals

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