EZSolution™ Nec-1s

A potent necroptosis inhibitor. Displays higher activity in inhibiting necroptosis in Jurkat cells than Nec-1 (Cat. No. 1864) (EC₅₀ = 210 nM versus EC₅₀ = 490 nM), as well as showing no nonspecific cytotoxicity at high concentrations (~100 mM). More useful for in-cell and in vivo experiments compared to Nec-1.

Alternate Name/Synonyms: 5-((7-Cl-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione); 7-Cl-O-Nec-1

Appearance: Liquid

Appearance: A 10 mM solution in anhydrous DMSO

Appearance: N/A

Appearance: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₃H₁₂ClN₃O₂

Molecular Weight: 277.71

Cell-Permeable?: Yes

Purity: ≥96% by LC-MS

Solubilities: N/A

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A potent necroptosis inhibitor

MDL Number: N/A

PubChem CID: 643953

SMILES: CN1C(=O)C(NC1=O)CC2=CNC3=C2C=CC=C3Cl

InChi: InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)

InChi Key: WIKGAEMMNQTUGL-UHFFFAOYSA-N

Category: Biochemicals