null

Human CellExp™ Acetylcholinesterase / AChE, Human Recombinant

(No reviews yet) Write a Review
SKU:
26-P1475
Availability:
Usually Shipped in 5 Working Days
Storage Temperature:
-20°C
Shipping Conditions:
Gel Pack
Shelf Life:
12 months
€351.00 - €906.00
Frequently bought together:

Description

Biomolecule/Target: N/A

Synonyms: Acetylcholinesterase (EC:3.1.1.7), AChE

Alternates names: Acetylcholinesterase (EC:3.1.1.7), AChE

Taglines: N/A

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 43

NCBI Gene Symbol: ACHE

Gene Source: Human

Accession #: P22303

Recombinant: True

Source: HEK 293 cells

Purity by SDS-PAGE #: >95%

Assay: N/A

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): The specific activity is > 500 U/mg. Specific activity was tested using BioVision’s Acetylcholinesterase Inhibitor Screening Kit (Catalog# K197).

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: One unit of active human Acetylcholinesterase is defined as the amount of enzyme that generates 1.0 µmol of substrate per min under the assay conditions at 37 ºC.

Molecular Weight: ~70 kDa (C terminal 6×His tag)

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.

Background Information: Acetylcholinesterase (AChE) is the major enzyme that hydrolyzes acetylcholine, a key neurotransmitter for synaptic transmission, into acetic acid and choline in both central and peripheral nervous systems. Mild inhibition of AChE has been shown to have therapeutic relevance in Alzheimer's disease (AD), myasthenia gravis, and glaucoma among others. In contrast, strong inhibition of AChE can lead to cholinergic poisoning. An irregular expression of AChE has also been found in different types of tumors, suggesting the involvement of AChE in the regulation of tumor development. Therefore AChE inhibitors could potentially be used in cancer treatment in future.

Amino acid sequence: Glu 32 – Leu 614

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans

View AllClose