Human CellExp™ CD304 / NRP1 / Neurophilin-1, Fc Tag, mouse recombinant

Biomolecule/Target: N/A

Synonyms: NRP1, Neuropilin-1, NRP, VEGF165R, CD304

Alternates names: NRP1, Neuropilin-1, NRP, VEGF165R, CD304

Taglines: A receptor involved in the development of the cardiovascular system

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 18186

NCBI Gene Symbol: Nrp1

Gene Source: Mouse

Accession #: P97333-1

Recombinant: True

Source: HEK 293 cells

Purity by SDS-PAGE #: >90%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: Less than 0.1 EU per μg by the LAL method.

Activity (Specifications/test method): Immobilized Human VEGF165, Tag Free at 2 μg/mL (100 μL/well) can bind Mouse NRP1, Mouse IgG2a Fc Tag with a linear range of 0.5-4 ng/mL

Biological activity: N/A

Results: N/A

Binding Capacity: Immobilized Human VEGF165, Tag Free at 2 μg/mL (100 μL/well) can bind Mouse NRP1, Mouse IgG2a Fc Tag with a linear range of 0.5-4 ng/mL

Unit Definition: N/A

Molecular Weight: This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 120.5 kDa. The protein migrates as 125 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

Background Information: Neuropilin-1 (NRP1) is also known as Vascular endothelial cell growth factor 165 receptor (VEGF165R), CD antigen CD304, which belongs to the neuropilin family. The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells.

Amino acid sequence: AA Phe 22 - Pro 856

Handling: Centrifuge the vial prior to opening.

Usage: N/A