Human CellExp™ Fc gamma RIV / CD16-2, Mouse recombinant

Biomolecule/Target: N/A

Synonyms: Fc gamma RIV, CD16-2, Fcgr4

Alternates names: Fc gamma RIV, CD16-2, Fcgr4

Taglines: Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a.

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 246256

NCBI Gene Symbol: Fcgr4

Gene Source: Mouse

Accession #: A0A0B4J1G0

Recombinant: True

Source: HEK 293 Cells

Purity by SDS-PAGE #: >90%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 22.8 kDa. The protein migrates as 28-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized powder

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

Background Information: FcgR4 (Low affinity immunoglobulin gamma Fc region receptor IV) is also known as CD16-2, FcgammaRIV, receptor for the Fc region of immunoglobulin gamma. Also acts as a receptor for the Fc region of immunoglobulin epsilon. Binds with intermediate affinity to both IgG2a and IgG2b. Does not display binding to IgG1 or IgG3. Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a. Binds with low affinity to both the a and b allotypes of IgE. Has also been shown to bind to IgE allotype a only but not to allotype b. Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions.

Amino acid sequence: AA Gly 21 - Gln 203

Handling: Centrifuge the vial prior to opening.

Usage: N/A