Human CellExp™ HDAC5, Catalytic Domain, Human Recombinant, Active

Biomolecule/Target: HDAC5

Synonyms: HDAC5, HD5, Histone Deacetylase 5

Alternates names: HDAC5, HD5, Histone Deacetylase 5, Antigen NY-CO-9, KIAA0600

Taglines: Key epigenetic regulator

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 10014

NCBI Gene Symbol: HDAC5

Gene Source: Human

Accession #: Q9UQL6

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGE #: ≥95%

Assay: SEC

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): Deacetylation activity was determined using the Boc-K(TFA)-AMC substrate.

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 45 kDa

Concentration: N/A

Appearance: Liquid

Physical form description: In 30 mM HEPES, 140 mM NaCl, 10 mM KCl, 3% glycerol, 0.25 mM TCEP, pH 7.6

Reconstitution Instructions: N/A

Background Information: Human HDAC5 is composed of 1122 amino acid residues. The deacetylase domain of HDAC5 is located at the C-terminal half of the molecule. The N-terminal non-deacetylase domain does not show any significant homology with any published sequence. Both domains are required for HDAC5- mediated repression of gene transcription. HDAC5 interacts with a growing number of transcriptional factors including MEF2A as well as other HDAC proteins. The interacting complexes bind to specific regions of chromatin and regulate gene transcription in these regions.

Amino acid sequence: N/A

Handling: Thaw on ice, and aliquot into smaller working quantities to avoid multiple freeze/thaw cycles.

Usage: For Research Use Only! Not to be used in humans