Human CellExp™LAG3 /CD223, human recombinant

Biomolecule/Target: LAG3 /CD223

Synonyms: LAG3, CD223, FDC

Alternates names: LAG3, CD223, FDC

Taglines: A protein involved in lymphocyte activation

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 3902

NCBI Gene Symbol: LAG3

Gene Source: Human

Accession #: P18627

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGE #: ≥95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <1 EU/μg by LAL method

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 47 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 μm filtered PBS (pH 7.4) with 5% trehalose

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4).

Background Information: Lymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC. It belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. LAG3/CD223 is one of the inhibitory receptors by negatively regulating cellular proliferation, activation, and homeostasis of T cells. LAG3 can bind to HLA class-II antigens and is involved in lymphocyte activation and autoimmunity. There are now LAG3 targeted therapies both in the clinic and in preclinical development, emphasizing the broad interest in this inhibitory receptor.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans