Human CellExp™ LAG3 / CD223, Fc Tag, human recombinant

Biomolecule/Target: LAG3

Synonyms: LAG3, CD223, FDC

Alternates names: LAG3, CD223, FDC

Taglines: A protein involved in lymphocyte activation

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 3902

NCBI Gene Symbol: LAG3

Gene Source: Human

Accession #: P18627

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGE #: > 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per/μg

Activity (Specifications/test method): Measured by its binding ability in a functional ELISA.

Biological activity: Immobilized Human LAG-3, Fc Tag at 2μg/mL (100 μL/well) can bind Anti-LAG3 MAb, Human IgG1 with a linear range of 0.1-2 ng/mL.

Results: N/A

Binding Capacity: Immobilized Human LAG-3, Fc Tag at 2μg/mL (100 μL/well) can bind Anti-LAG3 MAb, Human IgG1 with a linear range of 0.1-2 ng/mL.

Unit Definition: N/A

Molecular Weight: 72.3 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

Background Information: Lymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC, which belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. LAG3 /CD223 involved in lymphocyte activation. LAG3 /CD223 binds to HLA class-II antigens.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans