Human CellExp™ LILRB4 / CD85k / ILT3, Cynomolgus Recombinant

Biomolecule/Target: LILRB4

Synonyms: LILRB4, ILT3, LIR5, CD85K, HM18

Alternates names: LILRB4, ILT3, LIR5, CD85K, HM18

Taglines: Receptor for class I MHC antigens

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 107128256

NCBI Gene Symbol: LILRB4

Gene Source: Human

Accession #: XP_015297198.1

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGE #: > 85%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per/μg

Activity (Specifications/test method): Measured by its binding ability in a functional ELISA.

Biological activity: Immobilized Human ANGPTL7, His Tag at 5 μg/mL (100 μL/well) can bind Cynomolgus LILRB4, Fc Tag with a linear range of 10-156 ng/mL.

Results: N/A

Binding Capacity: Immobilized Human ANGPTL7, His Tag at 5 μg/mL (100 μL/well) can bind Cynomolgus LILRB4, Fc Tag with a linear range of 10-156 ng/mL.

Unit Definition: N/A

Molecular Weight: 52.7 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 μm filtered solution in PBS pH 7.4. Generally 5-8% Mannitol or Trehalose is added as a protectant before lyophilization.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

Background Information: Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family. LILRB4 / CD85K contains 2 Ig-like C2-type (immunoglobulin-like) domains. CD85K is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. LILRB4 / CD85K is receptor for class I MHC antigens. CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance. LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans