Human CellExp™ Progranulin, Mouse Recombinant

Biomolecule/Target: N/A

Synonyms: Proepithelin; PEPI; PC Cell-derived Growth Factor

Alternates names: Proepithelin; PEPI; PC Cell-derived Growth Factor

Taglines: Regulator of cell growth, wound healing, and tumorigenesis

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 10090

NCBI Gene Symbol: GRN

Gene Source: Mouse

Accession #: P28798

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGE #: ≥95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: HPLC

Endotoxin Level: <0.1 EU/μg purified protein

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: ~70.0 kDa

Concentration: 0.3 mg/ml

Appearance: Liquid

Physical form description: 0.2 μm-filtered solution in PBS

Reconstitution Instructions: N/A

Background Information: Progranulin (PGRN), also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides. It is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of fronto-temporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis. Mouse Recombinant Progranulin fused to FLAG® at C-terminus produced in HEK is a single, glycosylated, polypeptide chain purified by standard chromatographic techniques, containing 589 amino acids and having a molecular mass of ~70.0 kDa.

Amino acid sequence: Signal peptide and mouse Progranulin (aa 1-589) fused at the C-terminus to a FLAG®-tag.

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans