Human CellExp™ Progranulin, Rat Recombinant
- Usually Shipped in 5 Working Days
- Storage Temperature:
- Shipping Conditions:
- Gel pack
- Shelf Life:
- 12 months
Synonyms: Proepithelin; PEPI; PC Cell-derived Growth Factor
Alternates names: Proepithelin; PEPI; PC Cell-derived Growth Factor
Taglines: Regulator of cell growth, wound healing, and tumorigenesis
Country of Animal Origin: USA
NCBI Gene ID #.: 10116
NCBI Gene Symbol: GRN
Gene Source: Rat
Accession #: P23785
Source: HEK 293 cells
Purity by SDS-PAGE #: ≥95%
Assay #2: HPLC
Endotoxin Level: <0.1 EU/μg purified protein
Activity (Specifications/test method): N/A
Biological activity: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: ~65.0 kDa
Concentration: 0.3 mg/ml
Appearance: Lyophilized protein
Physical form description: Lyophilized from 0.2 µm-filtered solution in PBS.
Reconstitution Instructions: Reconstitute in dH2O before use.
Background Information: Progranulin (PGRN), also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides. It is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of fronto-temporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis. Rat Recombinant Progranulin fused to FLAG® at C-terminus produced in HEK is a single, glycosylated, polypeptide chain purified by standard chromatographic techniques, containing 602 amino acids and having a molecular mass of ~65.0 kDa.
Amino acid sequence: Signal peptide and rat Progranulin (aa 1-602) fused at the C-terminus to a FLAG®-tag.
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans