Human CellExp™ Progranulin (untagged), Human Recombinant
- Usually Shipped in 5 Working Days
- Storage Temperature:
- Reconstitute and store aliquots at -20 °C. Avoid repeated freeze-thaw cycles.
- Shipping Conditions:
- Gel pack
- Shelf Life:
- 12 months
Synonyms: Recombinant Human Progranulin (Untagged)
Alternates names: Proepithelin, PEPI, PC Cell-derived Growth Factor.
Taglines: Regulator of cell growth, wound healing, and inflammation linked to tumorigenesis
Country of Animal Origin: USA
NCBI Gene ID #.: 2896
NCBI Gene Symbol: GRN
Gene Source: Human
Accession #: P28799
Source: HEK 293 cells
Purity by SDS-PAGE #: ≥95%
Assay #2: N/A
Endotoxin Level: <0.1 EU/µg purified protein
Activity (Specifications/test method): N/A
Biological activity: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: ~74 kDa (observed due to glycosylation)
Concentration: 1 mg/ml
Appearance: Lyophilized protein
Physical form description: Lyophilized from PBS, pH 7.4
Reconstitution Instructions: N/A
Background Information: Progranulin (PGRN), also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides. It is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of fronto-temporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
Amino acid sequence: Signal peptide and human progranulin (aa 1-593) is untagged. Reflects the native sequence with no additional amino acids.
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans