Human CellExp™ SARS-CoV-2 S1 Protein (D614G), Recombinant

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SKU:
26-P1652
Availability:
Usually Shipped in 5 Working Days
Storage Temperature:
-20ºC
Shipping Conditions:
Gel Pack
Shelf Life:
12 months
€204.00 - €536.00
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Description

Biomolecule/Target: N/A

Synonyms: SARS-CoV-2 S1 Protein (D614G), Recombinant,SARS-CoV-2 S1 Protein (D614G),SARS-CoV-2 S1 (D614G),Human CellExp™ SARS-CoV-2 S1 (D614G), Recombinant,S1 Protein (D614G),Human CellExp™ SARS-CoV-2 S1 (D614G),Human CellExp™ SARS-CoV-2 S1 Protein (D614G),S1 (D614G),Human CellExp™ SARS-CoV-2 S1 (D614G)

Alternates names: SARS-CoV-2 S1 Protein (D614G), Recombinant,SARS-CoV-2 S1 Protein (D614G),SARS-CoV-2 S1 (D614G),Human CellExp™ SARS-CoV-2 S1 (D614G), Recombinant,S1 Protein (D614G),Human CellExp™ SARS-CoV-2 S1 (D614G),Human CellExp™ SARS-CoV-2 S1 Protein (D614G),S1 (D614G),Human CellExp™ SARS-CoV-2 S1 (D614G)

Taglines: Recombinant SARS-CoV-2 S1 spike protein with a mutation (D614G)

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: N/A

NCBI Gene Symbol: N/A

Gene Source: Recombinant

Accession #: N/A

Recombinant: TRUE

Source: HEK 293 cells

Purity by SDS-PAGE #: > 95% SDS-PAGE

Assay: N/A

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 120 kDa

Concentration: Lot dependent

Appearance: Lyophilized powder

Physical form description: N/A

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.

Background Information: SARS-CoV-2, the causative virus of COVID-19, uses the viral Spike (S) protein for host cell attachment and entry. The virus uses multiple factors including the human protease Furin, Angiotensin converting enzyme 2 (ACE2), Neuropilin-1 (NRP1) and the transmembrane protease serine 2 (TMPRSS2) for receptor interactions. The S protein has two domains S1 and S2, where S1 facilitates initial binding to the receptor and the S2 domain drives the membrane fusion and eventual entry of the virus. The S glycoprotein serves as an important target for monoclonal antibodies, entry inhibitors, and vaccines. Within the S1 protein, the conserved receptor-binding domain (RBD) binds with a high affinity for ACE2. Recently, a new strain of SARS-CoV-2 has been discovered with a mutation in the S1 protein (amino acid D614 to G614) outside the RBD. Early studies provide evidence that D614G SARS-CoV-2 virus strain is likely to be more infectious and is present in the majority of current infections globally.

Amino acid sequence: Val 16 - Arg 685

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans

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