Human CellExp™ Siglec-15, Human Recombinant

Biomolecule/Target: Siglec-15

Synonyms: Sialic acid-binding immunoglobulin (Ig)-like lectin 15, CD33 antigen-like 3, CD33 molecule-like 3, CD33L3

Alternates names: Sialic acid-binding immunoglobulin (Ig)-like lectin 15, CD33 antigen-like 3, CD33 molecule-like 3, CD33L3

Taglines: Transmembrane glycoprotein that controls innate and adoptive immune response.

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 284266

NCBI Gene Symbol: SIGLEC15

Gene Source: Human

Accession #: Q6ZMC9

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGE #: ≥95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 27 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 μm filtered PBS (pH 7.4) with 5% trehalose

Reconstitution Instructions: Reconstitute in sterile PBS, pH 7.4 up to 0.2µg/µl.

Background Information: Siglec-15 is a transmembrane glycoprotein of the siglecs family that participates in the immune regulatory systems through the recognition of their glycan ligands. Siglecs, short for sialic acid-binding immunoglobulin (Ig)-like lectins, are primarily expressed on the surface of immune cells and differentially control innate and adaptive immune responses. Mature human Siglec-15 consists of a 244 amino acid (aa) extracellular domain (ECD, Phe20 - Thr263) with two Ig-like domains, a 21 aa transmembrane segment (264-284), and a 44 aa cytoplasmic domain (285-328). Siglecs are attractive therapeutic targets because of their cell type-specific expression pattern, endocytic properties, high expression on certain lymphomas/leukemia, and ability to modulate receptor signaling. Because Siglec-15 is critical for proper development and function of osteoclasts, anti-Siglec-15 antibodies have therapeutic potential for treatment of osteoporosis.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans