Human CellExp™ Siglec-2, Fc Tag, Human Recombinant
- Usually Shipped in 5 Working Days
- Storage Temperature:
- Shipping Conditions:
- Gel Pack
- Shelf Life:
- 12 months
Synonyms: Siglec-8, SAF-2, SIGLEC8, SAF2
Alternates names: Siglec-8, SAF-2, SIGLEC8, SAF2
Taglines: Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells
Country of Animal Origin: USA
NCBI Gene ID #.: 27181
NCBI Gene Symbol: SIGLEC8
Gene Source: Human
Accession #: Q9NYZ4-1
Source: HEK 293 cells
Purity by SDS-PAGE #: >95%
Assay #2: N/A
Endotoxin Level: Less than 1.0 EU per μg by the LAL method.
Activity (Specifications/test method): N/A
Biological activity: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 64.3 kDa. The protein migrates as 70-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Appearance: Lyophilized powder
Physical form description: Lyophilized
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
Background Information: Siglec-8 is also known as SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L and sialic acid binding Ig like lectin 8. Siglec-8 was first identified by CD33 homology screening of ESTs from a cDNA library generated from a patient diagnosed with idiopathic hypereosinophilic syndrome and was originally termed SAF-2 (sialoadhesin family 2). At the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Two splice variants of Siglec-8 exist. The initially characterized form contains 431 amino acid residues in total, subsequently, a longer form of Siglec-8, initially termed Siglec-8L. Both forms of Siglec-8 are found in eosinophils and contain a V-set domain with lectin activity and two C2-type Ig repeat domains in the extracellular region.
Amino acid sequence: AA Met 17 - Ala 363
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans