Biovision
Anti-CD209 recMAb™ Antibody
- SKU:
- 26-A2193
- UPC:
- MPN:
- Availability:
- Usually Shipped in 5 Working Days
- Size:
- 100 µg
- Storage Condition:
- -20ºC
- Shipping Condition:
- Gel Pack
- Shelf Life:
- 12 months
Description
This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including leprosy and tuberculosis mycobacteria, the Ebola, hepatitis C, HIV-1 and Dengue viruses, and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain, a transmembrane region, and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CLEC4M (Gene ID: 10332), also known as L-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression on the surface of dendritic cells. Polymorphisms in the neck region are associated with protection from HIV-1 infection, while single nucleotide polymorphisms in the promoter of this gene are associated with differing resistance and susceptibility to and severity of the infectious disease, including rs4804803, which is associated with SARS severity.
Antibody Target: CD209
Target Alternative Name: CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, CIRE, DCSIGN, SIGNR5, SIGN-R1
Tag Line: Recombinant rabbit monoclonal antibody to detect the expression of CD209 in human samples
Category: Primary antibody
Host: Rabbit
Antibody Type: Monoclonal
Isotype: IgG
Clone#: C209/2749R
Species Reactivities: Human
Immunogen Sequence: Recombinant full-length human CD209 protein
Accession #: Q9NNX6
Gene Id: 30835
Appearance: Colorless liquid
Form: Liquid
Concentration: 1 mg/ml
Formulation: In 10 mM PBS
Purification: Protein A/G purified
Application: Immunohistochemistry (IHC)
Positive Control: N/A
Application And Usages: IHC (1-2 µg/ml)
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE
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