recMAb™ Anti-MYH11 Antibody

The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified.

Antibody Target: MYH11

Target Alternative Name: AAT4, FAA4, SMHC, SMMHC, KIAA0866, Smooth muscle myosin heavy chain 11, SM1, SM2

Tag Line: Recombinant rabbit monoclonal antibody to detect MyoD1 expression in human samples

Category: Primary antibody

Host: Rabbit

Antibody Type: Monoclonal

Isotype: IgG

Clone#: MYH11/2303R

Species Reactivities: Bovine,Rabbit,Porcine,Guinea Pig,Cat,Dog,Rat,Chicken,Human

Immunogen Sequence: Recombinant full-length human MYH11 protein

Accession #: P35749

Gene Id: 4329

Appearance: Colorless liquid

Form: Liquid

Concentration: 1 mg/ml

Formulation: In 10 mM PBS

Purification: Protein A/G purified

Application: Immunohistochemistry (IHC)

Positive Control: N/A

Application And Usages: IHC (1-2 µg/ml)

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: FALSE

Immunocytochemistry Verified: FALSE

Immunofluorescence Verified: FALSE

Immunoprecipitation Verified: FALSE

FACS Verified: FALSE

ELISA Verified: FALSE

ChIP Verified: FALSE

Dot Blot Verified: FALSE

Flow Cytometry Verified: FALSE