Biovision
EZSolution™ WP1066
- SKU:
- 26-2546
- Availability:
- Usually Shipped in 5 Working Days
- Size:
- 5 mg
- Storage Condition:
- -20°C
- Shipping Condition:
- gel pack
- Shelf Life:
- 12 months
Description
A potent, cell-permeable JAK2 inhibitor. A novel analog of the JAK2 inhibitor AG490 (Cat. No. 1570-5) that blocks STAT3 and phosphoinositide-3-kinase pathways. It is significantly more potent and active against human malignant glioma cells in vitro and in vivo than AG 490. Similar to AG490, WP1066 inhibits the phosphorylation of JAK2, but unlike AG490, WP1066 also degrades JAK2 protein, thus blocking its downstream signal transducer and activator of transcription (STAT) and phosphoinositide-3-kinase pathways to results in the activation of the caspase pathway.
Alternate Name/Synonyms: (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethy]-2-propenamide
Appearance: Liquid
Appearance: A 10 mM solution in anhydrous DMSO
Appearance: 857064-38-1
Appearance: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₇H₁₄BrN₃O
Molecular Weight: 356.22
Cell-Permeable?: Yes
Purity: ≥97% by HPLC
Solubilities: N/A
Handling: Protect from moisture and air
Country of Origin: USA
Tag Line: A JAK2 inhibitor
MDL Number: MFCD12912450
PubChem CID: 11210478
SMILES: CC(C1=CC=CC=C1)NC(=O)C(=CC2=NC(=CC=C2)Br)C#N
InChi: InChI=1S/C17H14BrN3O/c1-12(13-6-3-2-4-7-13)20-17(22)14(11-19)10-15-8-5-9-16(18)21-15/h2-10,12H,1H3,(H,20,22)/b14-10+/t12-/m0/s1
InChi Key: VFUAJMPDXIRPKO-LQELWAHVSA-N
Category: Biochemicals