EZSolution™ WP1066

A potent, cell-permeable JAK2 inhibitor. A novel analog of the JAK2 inhibitor AG490 (Cat. No. 1570-5) that blocks STAT3 and phosphoinositide-3-kinase pathways. It is significantly more potent and active against human malignant glioma cells in vitro and in vivo than AG 490. Similar to AG490, WP1066 inhibits the phosphorylation of JAK2, but unlike AG490, WP1066 also degrades JAK2 protein, thus blocking its downstream signal transducer and activator of transcription (STAT) and phosphoinositide-3-kinase pathways to results in the activation of the caspase pathway.

Alternate Name/Synonyms: (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethy]-2-propenamide

Appearance: Liquid

Appearance: A 10 mM solution in anhydrous DMSO

Appearance: 857064-38-1

Appearance: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₄BrN₃O

Molecular Weight: 356.22

Cell-Permeable?: Yes

Purity: ≥97% by HPLC

Solubilities: N/A

Handling: Protect from moisture and air

Country of Origin: USA

Tag Line: A JAK2 inhibitor

MDL Number: MFCD12912450

PubChem CID: 11210478

SMILES: CC(C1=CC=CC=C1)NC(=O)C(=CC2=NC(=CC=C2)Br)C#N

InChi: InChI=1S/C17H14BrN3O/c1-12(13-6-3-2-4-7-13)20-17(22)14(11-19)10-15-8-5-9-16(18)21-15/h2-10,12H,1H3,(H,20,22)/b14-10+/t12-/m0/s1

InChi Key: VFUAJMPDXIRPKO-LQELWAHVSA-N

Category: Biochemicals