EZSolution™ MAFP

MAFP is a potent inhibitor of fatty acid amide hydrolase (FAAH) (IC₅₀ = 2.5 nM). MAFP also binds to the CB1 receptor in rat brain membrane preparations (IC₅₀ = 20 nM). MAFP also acts as a selective, active-site directed, irreversible inhibitor of cPLA2 and iPLA2. It inhibits A23187-induced arachidonic acid release from human platelets with an IC₅₀ value of 0.6 µM. The IC₅₀ value for inhibition of iPLA2 from P388D1 cells is 0.5 µM.

Alternate Name/Synonyms: (5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraenyl-methyl ester phosphonofluoridic acid

Appearance: Liquid

Appearance: In methyl acetate

Appearance: 188404-10-6

Appearance: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₃₆FO₂P

Molecular Weight: 370.49

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: N/A

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A FAAH inhibitor

MDL Number: MFCD03095722

PubChem CID: 5353761

SMILES: CCCCCC=CCC=CCC=CCC=CCCCCP(=O)(OC)F

InChi: InChI=1S/C21H36FO2P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-2

InChi Key: KWKZCGMJGHHOKJ-SHDWVJIKSA-N

Category: Biochemicals