EZCyp™ Active Human Cytochrome P450 1A2

Biomolecule/Target: EZCyp™ Active Human CYP1A2

Synonyms: Cytochrome P450 1A, Cytochrome P450 1A2, Cyt1a2, CYPIA, CYPIA2, Cyp1A2, Microsomal cytochrome P450 1A2, active CYP1A2, human cyp1A2, human CYP1A2, recombinant CYP1A, CP12, P3-450, P450(PA)

Alternates names: Cytochrome P450 1A, Cytochrome P450 1A2, Cyt1a2, CYPIA, CYPIA2, Cyp1A2, Microsomal cytochrome P450 1A2, active CYP1A2, human cyp1A2, human CYP1A2, recombinant CYP1A, CP12, P3-450, P450(PA)

Taglines: Unique, cost-effective CYP1A2 catalytic system with active recombinant human CYP1A2 coexpressed with the active NADPH reductase in a semipermeable membrane system.

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 1544

NCBI Gene Symbol: CYP1A2

Gene Source: Human

Accession #: P05177

Recombinant: Yes

Source: Pichia pastoris

Purity by SDS-PAGE #: N/A

Assay: N/A

Purity: NA

Assay #2: NA

Endotoxin Level: NA

Activity (Specifications/test method): BioVision K852, Metabolite HPLC

Biological activity: NA

Results: NA

Binding Capacity: NA

Unit Definition: NA

Molecular Weight: 55 Kda

Concentration: N/A

Appearance: Dry powder

Physical form description: Lyophilized powder

Reconstitution Instructions: 100 mM Potassium Phosphate buffer, pH 7.7

Background Information: Cytochrome P450 1A2 (CYP1A2, EC 1.14.14.1) is a member of the cytochrome P450 monooxidase (CYP) family of microsomal xenobiotic metabolism enzymes. CYPs are membrane-bound hemeproteins responsible for Phase I biotransformation reactions, in which lipophilic drugs and other xenobiotic compounds are converted to more hydrophilic products to facilitate excretion from the body. CYP1A2 metabolizes many antidepressants and antipsychotic drugs, some of its substrates being caffeine, acetaminophen, fluvoxamine and Haloperidol. Expression of CYP1A2 appears to be induced by various dietary constituents like cabbages, cauliflower and broccoli. BioVision’s EZCypTM 1A2 is a permeabilized and stabilized dried yeast powder preparation containing recombinant human CYP1A2 and recombinant human P450 NADPH oxidoreductase co expressed in the same preparation.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans