Human CellExp™ HDAC11, Human Recombinant, Active

Biomolecule/Target: HDAC11

Synonyms: HDAC11, HD11, Histone Deacetylase 11

Alternates names: HDAC11, HD11, Histone Deacetylase 11

Taglines: A member of the Class IV HDAC subfamily

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 79885

NCBI Gene Symbol: HDAC11

Gene Source: Human

Accession #: Q96DB2

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGE #: ≥80%

Assay: SEC

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): Deacetylation activity was determined using a myristoylated substrate.

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 84 kDa

Concentration: N/A

Appearance: Liquid

Physical form description: In 30 mM HEPES, 140 mM NaCl, 10 mM KCl, 3% glycerol, 0.25 mM TCEP, pH 7.6

Reconstitution Instructions: N/A

Background Information: HDAC11 is a 39kDa protein and belongs to the Histone Deacetylase Class IV subfamily. The enzyme is primarily localized in the nucleus and shows high expression in specific tissues like brain, heart, skeletal muscle and kidney. It is the newest member of the HDAC family and hence very little is known about its functional role. Initial studies identified HDAC11 as a negative regulator of IL-10 production in APC cells. A recent study shows that HDAC11 is the most efficient fatty acid deacetylase of the HDAC family with catalytic efficiencies towards dodecanoylated and myristoylated substrates exceeding 70,000 M-1 s -1. Increasing body of evidence indicate a possible involvement of HDAC11 in diverse pathophysiological processes including immunomodulation, cancer pathogenesis, cellular differentiation etc

Amino acid sequence: N/A

Handling: Thaw on ice, and aliquot into smaller working quantities to avoid multiple freeze/thaw cycles.

Usage: For Research Use Only! Not to be used in humans