Biovision
Human CellExp™ B7-1/CD80, Human Recombinant
- SKU:
- 26-P1668
- UPC:
- MPN:
- Availability:
- Usually Shipped in 5 Working Days
- Storage Temperature:
- -20ºC
- Shipping Conditions:
- Gel Pack
- Shelf Life:
- 12 months
Description
Biomolecule/Target: N/A
Synonyms: T-lymphocyte activation antigen CD80; B7-1; Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B7.1; B7
Alternates names: T-lymphocyte activation antigen CD80; B7-1; Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B7.1; B7
Taglines: A critical regulator of T- and B-cell responses
Taglines: USA
Country of Animal Origin: USA
NCBI Gene ID #.: 941
NCBI Gene Symbol: N/A
Gene Source: Human
Accession #: P33681
Recombinant: True
Source: HEK 293 cells
Purity by SDS-PAGE #: > 95% SDS-PAGE
Assay: N/A
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): Human biotinylated CD28, Fc Tag (BioVision Cat. No. 9237) can bind to immobilized human CD80, Fc Tag at 1 µg/mL, 100 µL/well with a linear range of 0.01 – 0.27 µg/mL
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 50 kDa, calculated (with human Fc Tag fused to C-terminus)
Concentration: N/A
Appearance: Lyophilized protein
Physical form description: Lyophilized powder
Reconstitution Instructions: Reconstitute in sterile PBS, pH 7.4. Do not vortex.
Background Information: B-lymphocyte activation antigen B7, also known as B7-1 and Cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 and CD86 (B7-2), together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T and Bcell responses. Although both CTLA4 and CD28 can bind to the same ligands, CTLA4 binds to CD80 and CD86 with a 20 to 100 fold higher affinity than CD28 and is involved in the downregulation of the immune response. CD80 works in tandem with CD86 to prime T cells and plays a role in induction of innate immune responses by activating NF-κB signaling pathway in macrophages. Additionally, the up-regulation of CD80 has been linked to various autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus and sepsis. CD80 is thus regarded as a promising therapeutic target for autoimmune diseases and various carcinomas.
Amino acid sequence: Val 35 - Asn 242, with C-terminal human Fc tag
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
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