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- Human CellExp™ Biotinylated CD80/B7-1, Human Recombinant
Biovision
Human CellExp™ Biotinylated CD80/B7-1, Human Recombinant
- SKU:
- 26-P1672
- UPC:
- MPN:
- Availability:
- Usually Shipped in 5 Working Days
- Storage Temperature:
- -20°C
- Shipping Conditions:
- Gel Pack
- Shelf Life:
- 12 months
Description
Biomolecule/Target: N/A
Synonyms: T-lymphocyte activation antigen CD80; B7-1; Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B7.1; B7
Alternates names: T-lymphocyte activation antigen CD80; B7-1; Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B7.1; B7
Taglines: A critical regulator of T- and B-cell responses
Taglines: USA
Country of Animal Origin: USA
NCBI Gene ID #.: 941
NCBI Gene Symbol: N/A
Gene Source: Human
Accession #: P33681
Recombinant: True
Source: HEK 293 cells
Purity by SDS-PAGE #: > 95% by SDS-PAGE
Assay: N/A
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): Biotinylated CD-80-Fc can bind to immobilized Human CD28, Fc Tag (Cat. No. 9237 coated at 1 µg/mL, 100 µL/well) with a linear range of 0.03 – 0.81 µg/mL
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: ~51 kDa (Human Fc Tag fused to C-terminus, biotinylated)
Concentration: N/A
Appearance: Lyophilized protein
Physical form description: Lyophilized powder
Reconstitution Instructions: N/A
Background Information: B-lymphocyte activation antigen B7-1 (referred to as B7) also known as Cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). B7-1 and B7-2, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T and Bcell responses. Although both CTLA4 and CD28 can bind to the same ligands, CTLA4 binds to B71 and B72 with a 20 100 fold higher affinity than CD28 and is involved in the downregulation of the immune response. CD80 works in tandem with CD86 to prime T cells and plays a role in induction of innate immune responses by activating NF-κB-signaling pathway in macrophages. Additionally, the up-regulation of CD80 has been linked to various autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus and sepsis. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
Amino acid sequence: Val 35 - Asn 242
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
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