Human CellExp™ BCMA / TNFRSF17, human recombinant

Biomolecule/Target: CD269

Synonyms: TNFRSF17, CD269, BCM, BCMA

Alternates names: TNFRSF17, CD269, BCM, BCMA

Taglines: A member of the TNF receptor superfamily

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 608

NCBI Gene Symbol: TNR17

Gene Source: Human

Accession #: Q02223

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGE #: ≥90%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1 EU/μg

Activity (Specifications/test method): Measured by its binding ability in a functional ELISA.

Biological activity: Immobilized Human BCMA, His Tag at 5 μg/mL (100 μL/well) can bind Biotinylated Human BAFF with a linear range of 0.24-3.9 ng/mL.

Results: N/A

Binding Capacity: Immobilized Human BCMA, His Tag at 5 μg/mL (100 μL/well) can bind Biotinylated Human BAFF with a linear range of 0.24-3.9 ng/mL.

Unit Definition: N/A

Molecular Weight: 7.5 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally Mannitol or Trehalose is added as a protectant before lyophilization.

Reconstitution Instructions: Reconstitute in sterile deionized water to a concentration of 50 μg/ml.

Background Information: Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans