Human CellExp™ CD3 epsilon (His-tag) & CD3 delta Heterodimer

Biomolecule/Target: N/A

Synonyms: Human CellExp™ CD3 delta/epsilon,CD3E & CD3D,Human CellExp™ CD3 epsilon (His-tag) - CD3 delta Heterodimer,Human CellExp™ CD3 epsilon-CD3 delta Heterodimer,CD3 d/e,CD3 delta/epsilon,Human CellExp™ CD3 epsilon (His-tag) CD3 delta Heterodimer,CD3 delta & CD3 epsilon,CD3 epsilon (His-tag) - CD3 delta Heterodimer

Alternates names: Human CellExp™ CD3 delta/epsilon,CD3E & CD3D,Human CellExp™ CD3 epsilon (His-tag) - CD3 delta Heterodimer,Human CellExp™ CD3 epsilon-CD3 delta Heterodimer,CD3 d/e,CD3 delta/epsilon,Human CellExp™ CD3 epsilon (His-tag) CD3 delta Heterodimer,CD3 delta & CD3 epsilon,CD3 epsilon (His-tag) - CD3 delta Heterodimer

Taglines: CD3 epsilon (his-tag) and CD3 delta heterodimer important in coupling antigen recognition

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 916, 915

NCBI Gene Symbol: CD3E, CD3D

Gene Source: Human

Accession #: P07766, P04234

Recombinant: TRUE

Source: HEK 293 cells

Purity by SDS-PAGE #: ≥ 95% by SDS-PAGE

Assay: N/A

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: The calculated MW is 16 kDa (CD3E) and 13 kDa (CD3D)

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Reconstitute in sterile PBS (pH 7.4).

Background Information: T-cell surface glycoprotein CD3 delta & CD3 epsilon chain, also known as CD3D & CD3E or CD3D&CD3E respectively, are single-pass type I membrane proteins. CD3D, together with CD3E, CD3-gamma and CD3-zeta, and the T-cell receptor alpha/beta, and gamma/delta heterodimers, form the T cell receptor-CD3 complex. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Since CD3 is required for T-Cell activation, drugs and therapeutics targeting CD3 are being researched for diseases like Type 1 diabetes and other autoimmune diseases. For example, Muromonab-CD3, a monoclonal antibody targeting the CD3 receptor, is an immunosuppressant drug to reduce acute rejection in patients with organ transplants.

Amino acid sequence: Human CD3E (Asp 23 - Asp 126) (6x His-tag at C-Terminal) and CD3D (Phe 22 - Ala 105, no His-tag)

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans