Human CellExp™ PSMA / FOLH1, C-His Tag, human recombinant

Biomolecule/Target: PSMA

Synonyms: Prostatespecific membrane antigen; Glutamate carboxypeptidase 2; PSMA; PSM; mGCP; GCPII; FGCP; NAALADase I; cell growth-inhibiting gene 27 protein; Folate hydrolase 1; Folylpoly gamma glutamate carboxypeptidase; glutamate carboxypeptidase II; Membrane glutamate carboxypeptidase; N-acetylated-alpha-linked acidic dipeptidase I; Pteroylpoly-gamma-glutamate carboxypeptidase

Alternates names: Prostatespecific membrane antigen; Glutamate carboxypeptidase 2; PSMA; PSM; mGCP; GCPII; FGCP; NAALADase I; cell growth-inhibiting gene 27 protein; Folate hydrolase 1; Folylpoly gamma glutamate carboxypeptidase; glutamate carboxypeptidase II; Membrane glutamate carboxypeptidase; N-acetylated-alpha-linked acidic dipeptidase I; Pteroylpoly-gamma-glutamate carboxypeptidase

Taglines: Extracellular Domain of PSMA fused to 6x His tag at the C-terminus.

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 2346

NCBI Gene Symbol: PSMA

Gene Source: Human

Accession #: Q04609

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGE #: ≥95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: HPLC

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: This protein is fused to 6x His tag at the C-terminus and has a calculated MW of 81 kDa. The protein migrates as ~100 kDa under reducing conditions (SDS-PAGE) due to glycosylation.

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized from filtered PBS (pH 7.4) with Trehalose (5%)

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in PBS (pH 7.4). Do not vortex.

Background Information: Human Prostate Specific Membrane Antigen (PSMA), a tumor marker in prostate cancer encoded by FOLH1 gene, is a surface glycoprotein with high expression in prostate epithelium. PSMA expression level increases in primary and metastatic prostate cancer and the neovasculature of nonprostatic epithelial malignancies. Overexpression of PSMA is correlated with high tumor grade, non-diploid tumors, and advanced tumor stage. PSMA is used as a diagnostic and prognostic indicator of prostate cancer, and as a possible marker for various neurological disorders such as schizophrenia, Alzheimer disease and Huntington disease. It is also recognized as a viable target for cancer therapy.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans