Human CellExp™ Integrin alpha 6 beta 1 Heterodimer, Human Recombinant

Biomolecule/Target: ITGA6, ITGB1

Synonyms: Integrin alpha 6 beta 1, ITGA6B1, ITGA6&ITGB1, CD49f, VLA-6

Alternates names: Integrin alpha 6 beta 1, ITGA6B1, ITGA6&ITGB1, CD49f, VLA-6

Taglines: Hetrodimer integrin (alpha 6 beta 1) negatively regulate erbB2/HER2 signaling

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 3655, 3688

NCBI Gene Symbol: ITGA6, ITGB1

Gene Source: Human

Accession #: P23229, P05556

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGE #: > 90%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per/μg

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 116.8 kDa, 83.7 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

Background Information: Integrin alpha 6 beta 1, also called platelet glycoprotein GPIc-IIa, is a receptor for laminin on platelets. The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. ITGA6 has been shown to interact with TSPAN4 and GIPC1.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans