Human CellExp™ Netrin-1, human recombinant

Biomolecule/Target: Netrin-1

Synonyms: NTN1

Alternates names: NTN1

Taglines: Involved in tumorigenesis by regulating apoptosis.

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 9423

NCBI Gene Symbol: NTN1

Gene Source: Human

Accession #: O95631

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGE #: ≥95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <0.1 EU/μg by LAL method

Activity (Specifications/test method): Induces axon outgrowth.

Biological activity: Induces axon outgrowth.

Results: Induces axon outgrowth.

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: ~80.0 kDa. Human netrin-1 (aa 25-604) is fused at the C-terminus to a FLAG®-tag.

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized in PBS with trehalose and Brij 35.

Reconstitution Instructions: Reconstitute with 100 μl sterile distilled water.

Background Information: Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also Involved in tumorigenesis by regulating apoptosis.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans