Human CellExp™ PD-1 /PDCD1, human recombinant

Biomolecule/Target: PD-1/PDCD1

Synonyms: PD, PD 1, PD 1 protein, PD 1 recombinant protein, human PD 1 protein, human recombinant PD 1 protein, human recombinant PD 1, human PD 1, recombinant PD 1, Human cell expressed PD 1, Human cell expressed PD 1 protein, Human cell expressed recombinant PD 1

Alternates names: PDCD1, PD1, CD279, SLEB2, hPD-1, hPD-l

Taglines: Inhibits the T-cell proliferation and production of IL-1, IL-4, IL-10 and IFN-? by suppressing the activation and transduction of PI3K/AKT pathway.

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 5133

NCBI Gene Symbol: PDCD1

Gene Source: Human

Accession #: Q15116

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGE #: ?95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): Measured by its binding ability in a functional ELISA

Biological activity: Immobilized Human PD-1, His Tag at 5?g/mL (100 ?L/well) can bind Human PD-L1, His Tag with a linear range of 0.15-1.25 ?g/mL

Results: N/A

Binding Capacity: Immobilized Human PD-1, His Tag at 5?g/mL (100 ?L/well) can bind Human PD-L1, His Tag with a linear range of 0.15-1.25 ?g/mL

Unit Definition: N/A

Molecular Weight: This protein is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 17.2 kDa. The predicted N-terminus is Leu 25. DTT-reduced Protein migrates as 25-40 kDa in SDS-PAGE due to glycosylation.

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 ?m filtered solution in PBS pH 7.5

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Background Information: Programmed cell death 1 (PD1) is a cell surface membrane protein of the immunoglobulin superfamily. It is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD1 functions as an inhibitory cell su

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans