Human CellExp™ VEGF R3 / FLT4, Fc Tag, Mouse Recombinant

Biomolecule/Target: N/A

Synonyms: Flt-4, FLT4, LMPH1A, PCLFLT41, VEGFR3, VEGFR-3, FLT-4, FLT-41, FLT41, PCL

Alternates names: Flt-4, FLT4, LMPH1A, PCLFLT41, VEGFR3, VEGFR-3, FLT-4, FLT-41, FLT41, PCL

Taglines: Cell-surface receptor for VEGFC and VEGFD

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 14257

NCBI Gene Symbol: Flt4

Gene Source: Murine

Accession #: P35917-1

Recombinant: True

Source: HEK 293 cells

Purity by SDS-PAGE #: >95%

Assay: SDS-PAGE.

Purity: N/A

Assay #2: N/A

Endotoxin Level: Less than 0.1 EU per μg by the LAL method.

Activity (Specifications/test method): Immobilized Human VEGF-C, His Tag at 5 μg/mL (100 μL/well) can bind Mouse VEGF R3, Mouse Fc Tag, low endotoxin with a linear range of 1-10 ng/mL

Biological activity: N/A

Results: N/A

Binding Capacity: Immobilized Human VEGF-C, His Tag at 5 μg/mL (100 μL/well) can bind Mouse VEGF R3, Mouse Fc Tag, low endotoxin with a linear range of 1-10 ng/mL

Unit Definition: N/A

Molecular Weight: This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 111.5 kDa. The protein migrates as 116-125 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

Background Information: Vascular endothelial growth factor receptor 3 (VEGF R3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). VEGF R3 mediates lymphangiogenesis in response to VEGF-C and VEGF-D. VEGF R3 is widely expressed in the early embryo but becomes restricted to lymphatic endothelia at later stages of development. It is likely that VEGF R3 may be important for lymph angiogenesis.

Amino acid sequence: Tyr 25 - Asp 770

Handling: Centrifuge the vial prior to opening.

Usage: N/A