Human CellExp™ VEGF R3, Fc Tag, human recombinant

Biomolecule/Target: FLT4

Synonyms: Flt-4, FLT4, LMPH1A, PCLFLT41, VEGFR3, VEGFR-3, FLT-4, FLT-41, FLT41, PCL

Alternates names: Flt-4, FLT4, LMPH1A, PCLFLT41, VEGFR3, VEGFR-3, FLT-4, FLT-41, FLT41, PCL

Taglines: Cell-surface receptor for VEGFC and VEGFD

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 2324

NCBI Gene Symbol: FLT4

Gene Source: Human

Accession #: P35916

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGE #: > 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per/μg

Activity (Specifications/test method): Measured by its binding ability in a functional ELISA.

Biological activity: Immobilized Human VEGF-C, His Tag at 5μg/mL (100 μL/well) can bind Human VEGF R3, Fc Tag with a linear range of 0.6-10 ng/mL. Immobilized Human VEGF R3, Fc Tag at 5μg/mL (100 μL/well) can bind Human VEGF-D, His Tag, Streptavidin Tag with a linear range of 0.08-0.6 μg/mL.

Results: N/A

Binding Capacity: Immobilized Human VEGF-C, His Tag at 5μg/mL (100 μL/well) can bind Human VEGF R3, Fc Tag with a linear range of 0.6-10 ng/mL. Immobilized Human VEGF R3, Fc Tag at 5μg/mL (100 μL/well) can bind Human VEGF-D, His Tag, Streptavidin Tag with a linear range of 0.08-0.6 μg/mL.

Unit Definition: N/A

Molecular Weight: 111.2 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

Background Information: Vascular endothelial growth factor receptor 3 (VEGF R3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). VEGF R3 mediates lymphangiogenesis in response to VEGF-C and VEGF-D. VEGF R3 is widely expressed in the early embryo but becomes restricted to lymphatic endothelia at later stages of development. It is likely that VEGF R3 may be important for lymph angiogenesis.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans