BioSim™ Denosumab (Human) ELISA Kit

Denosumab is a human monoclonal antibody that binds to RANKL, a transmembrane or soluble protein essential for the formation, function, and survival of osteoclasts, the cells responsible for bone resorption. Denosumab prevents RANKL from activating its receptor, RANK, on the surface of osteoclasts and their precursors. Prevention of the RANKL/RANK interaction inhibits osteoclast formation, function, and survival, thereby decreasing bone resorption and increasing bone mass and strength in both cortical and trabecular bone. BioSimTM Denosumab ELISA kit has been developed for specific quantification of Denosumab concentration in human serum or plasma with high sensitivity and reproducibility.

Alternate Name: ODF, OPGL, sOdf, CD254, OPTB2, RANKL, TNLG6B, TRANCE, hRANKL2, TNFSF11, CAS 615258-40-7

Tag Line: A Sandwich ELISA kit for the quantitative measurement of free Denosumab in human serum or plasma.

Summary: N/A

Detection Method: Absorbance (450 nm)

Sample Type: Human serum and plasma

Species Reactivity: Human

Applications: This ELISA kit is used for quantitative measurement of Denosumab in human serum and plasma

Features & Benefits: • Easy, convenient, sensitive and time-saving method to measure the level of Denosumab in human serum and plasma. • Detection Range: 3 - 300 ng/ml • Sensitivity: 3 ng/ml • Assay Precision: Intra-Assay: CV < 15%; Inter-Assay: CV < 15% (CV (%) = SD/mean X 100) • Recovery rate: 85 – 115% with normal human serum samples with known concentrations • Cross Reactivity: There is no cross reaction with native serum immunoglobulins and tested monoclonal antibodies such as infliximab (Remicade®), adalimumab (Humira®), trastuzumab (Herceptin®) and bevacizumab (Avastin®)