Biovision
recMAb™ Anti-PMS2 Antibody
- SKU:
- 26-A2223
- UPC:
- MPN:
- Availability:
- Usually Shipped in 5 Working Days
- Size:
- 100 µg
- Storage Condition:
- -20ºC
- Shipping Condition:
- Gel Pack
- Shelf Life:
- 12 months
Description
The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome.
Antibody Target: PMS2
Target Alternative Name: MLH4, PMSL2, HNPCC4, PMS2CL, H_DJ0042M02.9
Tag Line: Recombinant rabbit monoclonal antibody to detect PMS2 expression in human samples
Category: Primary antibody
Host: Rabbit
Antibody Type: Monoclonal
Isotype: IgG
Clone#: PMS2/4373R
Species Reactivities: Human
Immunogen Sequence: Synthetic peptide targeting residues within aa 1-100 of PMS2
Accession #: P54278
Gene Id: 5395
Appearance: Colorless liquid
Form: Liquid
Concentration: 1 mg/ml
Formulation: In 10 mM PBS
Purification: Protein A/G purified
Application: Immunohistochemistry (IHC)
Positive Control: N/A
Application And Usages: IHC (1-2 µg/ml)
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE
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