EZCyp™ Active Human Cytochrome P450 3A4

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SKU:
26-7872
Availability:
Usually Shipped in 5 Working Days
Storage Temperature:
-20°C
Shipping Conditions:
gel pack
Shelf Life:
12 months
zł989.28 - zł2,963.26
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Description

Biomolecule/Target: EZCyp™ Active Human CYP3A4

Synonyms: Cytochrome P450 3A, Cytochrome P450 3A4, Cyt3A4, CYPIIIA, CYPIIIA4, CYP3A, CYP3A4, Microsomal cytochrome P450 3A4, active CYP3A, human cyp3a, human CYP3A4, recombinant human CYP3A4

Alternates names: Cytochrome P450 3A, Cytochrome P450 3A4, Cyt3A4, CYPIIIA, CYPIIIA4, CYP3A, CYP3A4, Microsomal cytochrome P450 3A4, active CYP3A, human cyp3a, human CYP3A4, recombinant human CYP3A4

Taglines: Unique, cost-effective CYP3A4 catalytic system with active recombinant human CYP3A4 coexpressed with the active NADPH reductase in a semipermeable membrane system.

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 1576

NCBI Gene Symbol: CYP3A4

Gene Source: Human

Accession #: P08684

Recombinant: Yes

Source: Pichia pastoris

Purity by SDS-PAGE #: N/A

Assay: N/A

Purity: NA

Assay #2: NA

Endotoxin Level: NA

Activity (Specifications/test method): BioVision K701, Metabolite HPLC

Biological activity: NA

Results: NA

Binding Capacity: NA

Unit Definition: NA

Molecular Weight: 55 KDa

Concentration: N/A

Appearance: Dry powder

Physical form description: Lyophilized powder

Reconstitution Instructions: 100 mM Potassium Phosphate buffer, pH 7.7

Background Information: Cytochrome P450 3A4 (CYP3A4, EC 1.14.13.157) is a member of the cytochrome P450 monooxidase (CYP) family of microsomal xenobiotic metabolism enzymes. CYPs are membrane-bound hemeproteins responsible for Phase I biotransformation reactions, in which lipophilic drugs and other xenobiotic compounds are transformed to more hydrophilic products to facilitate excretion from the body. CYP3A4 is expressed in high levels in the liver and intestines, where it catalyzes oxidation of an extraordinarily wide variety of structurally distinct ligands. More than half of all small molecule drugs commonly used by humans are metabolized by CYP3A4. BioVision’s EZCypTM 3A4 is a permeabilized and stabilized dried yeast powder preparation containing recombinant human CYP 3A4 and recombinant human P450 NADPH oxidoreductase co expressed in the same preparation.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans

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