Human CellExp™ ACE1, Human Recombinant

Biomolecule/Target: N/A

Synonyms: Angiotensin-Converting Enzyme, ACE1, ACE, CD antigen CD143, DCP1, DCP, Dipeptidyl carboxypeptidase I, Kininase II, Peptidyl-dipeptidase A, Peptidyldipeptide Hydrolase, EC 3.4.15.1, UniProtKB - P12821,Human CellExp™ ACE1, Human Recombinant,Human Recombinant ACE1,ACE1, Human Recombinant,Human Cell Expressed ACE1, Human Recombinant,ACE 1

Alternates names: Angiotensin-Converting Enzyme, ACE1, ACE, CD antigen CD143, DCP1, DCP, Dipeptidyl carboxypeptidase I, Kininase II, Peptidyl-dipeptidase A, Peptidyldipeptide Hydrolase, EC 3.4.15.1, UniProtKB - P12821,Human CellExp™ ACE1, Human Recombinant,Human Recombinant ACE1,ACE1, Human Recombinant,Human Cell Expressed ACE1, Human Recombinant,ACE 1

Taglines: Human cell expressed human recombinant ACE1 protein

Taglines: USA

Country of Animal Origin: N/A

NCBI Gene ID #.: N/A

NCBI Gene Symbol: N/A

Gene Source: Human

Accession #: P12821

Recombinant: TRUE

Source: HEK 293 cells

Purity by SDS-PAGE #: ≥ 95% by SDS-PAGE

Assay: N/A

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): The specific activity is > 200 U/mg, assayed using BioVision’s Angiotensin I Converting Enzyme Activity (ACE1) Assay Kit (Fluorometric) (BV Cat # K227-100).

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: One unit of ACE1 activity is the amount of enzyme that catalyzes the release of 1 nmol of Abz per min from the substrate under the assay conditions at 37 °C using K227-100.

Molecular Weight: 170 kDa (His-tag at the C-terminus)

Concentration: Lot dependent

Appearance: Liquid

Physical form description: Liquid

Reconstitution Instructions: N/A

Background Information: The angiotensin 1 converting enzyme (ACE1) is a zinc metalloproteinase. It functions as a central component of the well acknowledged renin–angiotensin system (RAS), where ACE plays an important physiological role in regulation of blood pressure via the conversion of angiotensin I to angiotensin II. Inhibition of ACE has been a targeted therapeutic strategy for treating hypertension. ACE can be specifically inhibited by peptide like lisinopril, captopril and enalaprilat. ACE is also crucial for fertilization for releasing the proteins anchored to glycosylphosphatidylinositol (GPI) in sperm membrane. Germinal angiotensin-converting enzyme (gACE) was shown to be undetectable in sperm from patients with fertilization failure. ACE1 and its homologue, ACE2, have been mostly associated with hypertension disorders. SARS-CoV-2 virus has been shown to exploit ACE2 protein to enter cells. The differences in the course of SARS-CoV-2 infection have been attributed to difference in expression levels and function of ACE proteins.

Amino acid sequence: 30-1232

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans