Human CellExp™ VSIG4, human recombinant

Biomolecule/Target: VSIG4

Synonyms: V-set and immunoglobulin domain containing 4; Z39Ig; CRIg

Alternates names: V-set and immunoglobulin domain containing 4; Z39Ig; CRIg

Taglines: V-set and immunoglobulin domain-containing protein 4

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 11326

NCBI Gene Symbol: VSIG4

Gene Source: Human

Accession #: Q9Y279

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGE #: ≥ 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 0.06 EU/mg

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 68 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.2μm-filtered solution in PBS.

Reconstitution Instructions: Reconstitute in 1X PBS to the desired protein concentration.

Background Information: VSIG4 (V-set and immunoglobulin domain containing 4), as known as complement receptor of the immunoglobulin superfamily (CRIg) and Z39Ig. It is a B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type I g domain and a truncated C-type I g domain. VSIG4 is exclusively expressed on tissue resident macrophages and binds to multimers of C3b and iC3b that are covalently attached to particle surfaces. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans