Human CellExp™ Azurocidin, human recombinant

Biomolecule/Target: Azurocidin

Synonyms: AZU1, Azurocidin, HBP, AZAMP, AZU, CAP37, HUMAZUR, NAZC

Alternates names: AZU1, Azurocidin, HBP, AZAMP, AZU, CAP37, HUMAZUR, NAZC

Taglines: >95% Pure, Human cell expressed azurocidin

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 566

NCBI Gene Symbol: AZU1

Gene Source: Human

Accession #: P20160

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGE #: ≥95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per μg of the protein by the LAL method.

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 25 kDa. The predicted N-terminus is Ile 27. DTT-reduced Protein migrates as 32-40 kDa due to glycosylation.

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in PBS, pH 7.4. Do not vortex.

Background Information: Azurocidin (AZU1) is also known as Heparin-binding protein (HBP), Cationic antimicrobial protein CAP37, is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. which belongs to the peptidase S1 family and elastase subfamily. AZU1 / HBP contains 1 peptidase S1 domain. AZU1 binds heparin. The cytotoxic action of AZU1 is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. AZU1 may play a role in mediating recruitment of monocytes in the second wave of inflammation.

Amino acid sequence: Ile 27 – Pro 250

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans