Human CellExp™ BMP-2, Human Recombinant
- Usually Shipped in 5 Working Days
- Storage Temperature:
- Shipping Conditions:
- gel pack
- Shelf Life:
- 12 months
Synonyms: Human Cellexp Human Recombinant BMP-2
Alternates names: BMP-2, BMP2A
Taglines: A protein involved in the hedgehog and TGF beta signaling pathway
Country of Animal Origin: USA
NCBI Gene ID #.: 650
NCBI Gene Symbol: BMP2
Gene Source: Human
Accession #: P12643
Source: Human 293 cell expressed
Purity by SDS-PAGE #: ≥95%
Assay #2: N/A
Endotoxin Level: < 1.0 EU per 1 μg of protein
Activity (Specifications/test method): N/A
Biological activity: ED₅₀ is typically 20 to 100 ng/mL. The specific activity was determined by the dose dependent induction of alkaline phosphatase production in the ATDC-5 cell line (Mouse chondrogenic cell line).
Results: 20 to 100 ng/ml
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 30 to 38 kDa, homodimer, glycosylated.
Physical form description: Lyophilized from a solution of 50 mM sodium acetate, pH 4.5, with 50 mM NaCl.
Reconstitution Instructions: Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.
Background Information: BMP2 belongs to the transforming growth factor-beta (TGFβ) superfamily. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. In addition to its osteogenic activity, BMP-2 also plays an important role in cardiac morphogenesis. BMP-2 is expressed in a variety of tissues such as lung, spleen, brain, liver, prostate ovary, and small intestine. BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva. BioVision’s BMP-2 is produced in a serum-free, chemically defined media. Production in human 293 cells offers authentic glycosylation, contributing to stability in cell growth media and other applications.
Amino acid sequence: N/A
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans