Biovision
Human CellExp™ BMP-4, Human Recombinant
- SKU:
- 26-6445
- Availability:
- Usually Shipped in 5 Working Days
- Storage Temperature:
- -20°C
- Shipping Conditions:
- gel pack
- Shelf Life:
- 12 months
Description
Biomolecule/Target: N/A
Synonyms: Human Cellexp Human Recombinant BMP-4
Alternates names: BMP4, ZYME, BMP2B, BMP2B1
Taglines: A protein involved in bone and cartilage development
Taglines: USA
Country of Animal Origin: USA
NCBI Gene ID #.: 652
NCBI Gene Symbol: BMP4
Gene Source: Human
Accession #: P12644
Recombinant: Yes
Source: Human 293 cell expressed
Purity by SDS-PAGE #: ≥95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: < 1.0 EU per 1 μg of protein
Activity (Specifications/test method): N/A
Biological activity: ED₅₀ is typically 2 to 10 ng/mL. The specific activity was determined by the dose dependent induction of alkaline phosphatase production in the ATDC-5 cell line (Mouse chondrogenic cell line).
Results: 2 to 10 ng/ml
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 34 kDa, homodimer, glycosylated.
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from a PBS solution.
Reconstitution Instructions: Reconstitute in sterile 4 mM HCl containing 0.1% endotoxin-free recombinant human serum albumin.
Background Information: BMP4 belongs to the transforming growth factor-beta (TGFβ) superfamily. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. BMP-4 plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.
Amino acid sequence: N/A
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans