Human CellExp™ BMP-2, Human Recombinant

Biomolecule/Target: N/A

Synonyms: Human Cellexp Human Recombinant BMP-2

Alternates names: BMP-2, BMP2A

Taglines: A protein involved in the hedgehog and TGF beta signaling pathway

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 650

NCBI Gene Symbol: BMP2

Gene Source: Human

Accession #: P12643

Recombinant: Yes

Source: Human 293 cell expressed

Purity by SDS-PAGE #: ≥95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per 1 μg of protein

Activity (Specifications/test method): N/A

Biological activity: ED₅₀ is typically 20 to 100 ng/mL. The specific activity was determined by the dose dependent induction of alkaline phosphatase production in the ATDC-5 cell line (Mouse chondrogenic cell line).

Results: 20 to 100 ng/ml

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 30 to 38 kDa, homodimer, glycosylated.

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from a solution of 50 mM sodium acetate, pH 4.5, with 50 mM NaCl.

Reconstitution Instructions: Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.

Background Information: BMP2 belongs to the transforming growth factor-beta (TGFβ) superfamily. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. In addition to its osteogenic activity, BMP-2 also plays an important role in cardiac morphogenesis. BMP-2 is expressed in a variety of tissues such as lung, spleen, brain, liver, prostate ovary, and small intestine. BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva. BioVision’s BMP-2 is produced in a serum-free, chemically defined media. Production in human 293 cells offers authentic glycosylation, contributing to stability in cell growth media and other applications.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans