Human CellExp™ IL-2, Human Recombinant

Biomolecule/Target: N/A

Synonyms: Human Cellexp Human Recombinant IL-2

Alternates names: T-cell growth factor (TCGF), Aldesleukin, Lymphokine, IL-2.

Taglines: A regulator of lymphocyte activities

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 3558

NCBI Gene Symbol: IL2

Gene Source: Human

Accession #: P60568

Recombinant: Yes

Source: Human 293 cell expressed

Purity by SDS-PAGE #: ≥95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per 1 μg of protein

Activity (Specifications/test method): N/A

Biological activity: ED₅is typically 0.2 to 2 ng/mL. The specific activity was determined by the dose-dependent stimulation of the proliferation of mouse CTLL-2 cells (mouse cytotoxic T cell line).

Results: 0.2 to 2 ng/ml

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 15 kDa, monomer, glycosylated

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from a PBS solution.

Reconstitution Instructions: Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Background Information: IL-2 is a potent immuno-modulator, which mediates a wide range of immune and inflammatory responses and is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans