Human CellExp™ CD163, Human recombinant

Biomolecule/Target: CD163

Synonyms: CD163, M130

Alternates names: CD163, M130

Taglines: Scavenger receptor for the hemoglobin-haptoglobin complex

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 9332

NCBI Gene Symbol: CD163

Gene Source: Human

Accession #: Q86VB7

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGE #: ≥95%

Assay: SDS-PAGE

Purity: ≥95%

Assay #2: N/A

Endotoxin Level: < 1 EU/μg

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: This protein is fused with a 6× His tag at C-terminus and has a calculated MW of 110.4 kDa. The protein migrates as 135-140 kDa in SDS-PAGE due to glycosylation.

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

Reconstitution Instructions: Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/ml

Background Information: Scavenger receptor cysteine-rich type 1 protein M130 (CD163) is also known as hemoglobin scavenger receptor, which is a scavenger receptor for the hemoglobin-haptoglobin complex. CD163 has also been shown to mark cells of monocyte/macrophage lineage. A soluble form of the receptor exists in plasma, commonly denoted sCD163. sCD163 is generated by ectodomain shedding of the membrane bound receptor. sCD163 is upregulated in a large range of inflammatory diseases including liver cirrhosis, type 2 diabetes, macrophage activation syndrome, Gaucher’s disease, sepsis, HIV infection, rheumatoid arthritis and Hodgkin Lymphoma.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans