Human CellExp™ CD38, Human Recombinant
- Usually Shipped in 5 Working Days
- Storage Temperature:
- Store lyophilized protein at -20 °C. Once reconstituted, aliquot and store at -20 °C or -70 °C. Avoid repeated freeze-thaw cycles.
- Shipping Conditions:
- Gel pack
- Shelf Life:
- 12 months
Synonyms: ADP-ribosyl Cyclase 1, Cyclic ADP-ribose Hydrolase 1, ADPRC 1, T10
Alternates names: ADP-ribosyl Cyclase 1, Cyclic ADP-ribose Hydrolase 1, ADPRC 1, T10
Country of Animal Origin: USA
NCBI Gene ID #.: 952
NCBI Gene Symbol: CD38
Gene Source: Human
Accession #: P28907
Source: HEK 293 cells
Purity by SDS-PAGE #: ≥ 98%
Purity: 95% SDS-PAGE
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): The specific (Cyclase) activity is > 10 mU/mg, as measured under the described conditions using BioVision’s CD38 (Cyclase) Activity Assay Kit (Cat. No. K2042).
Biological activity: N/A
Binding Capacity: N/A
Unit Definition: One unit is the amount of enzyme that cleaves the substrate nicotinamide guanine dinucleotide (NGD+) and liberates 1 μmol MAP per minute at pH 7.5 and 37 °C
Molecular Weight: 56 kDa, calculated (with human Fc Tag fused to C-terminus)
Physical form description: Lyophilized from 0.22 µm filtered solution in PBS (pH 7.4) with 5% Trehalose
Reconstitution Instructions: Reconstitute in 1X PBS to the desired protein concentration.
Background Information: CD38, also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications including social amnesia possibly related to autism. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism, as well as some genetically determined conditions.
Amino acid sequence: N/A
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans