Human CellExp™ CD45, human recombinant

Biomolecule/Target: PTPRC

Synonyms: LCA; LY5; B220; T200; CD45R; GP180; PTPRC

Alternates names: LCA; LY5; B220; T200; CD45R; GP180; PTPRC

Taglines: Receptor-type tyrosine-protein phosphatase C

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 5788

NCBI Gene Symbol: PTPRC

Gene Source: Human

Accession #: P08575

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGE #: ≥ 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 5 EU/mg

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 65kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.2μm-filtered solution in PBS.

Reconstitution Instructions: Reconstitute in 1X PBS to the desired protein concentration.

Background Information: Protein tyrosine phosphatase, receptor type C (CD45), also known as PTPRC is a member of the protein tyrosine phosphatase (PTP) family which is known for its function to serve as signaling molecules and to regulate a variety of cellular processes such as cell proliferation, differentiation, mitotic cycle and oncogenic transformation. CD45 is found expression specifically in hemotopietic cells. CD45 consists of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. It serves as an essential regulator of T-cell and B-cell antigen receptor signaling through either direct interaction with components of the antigen receptor complexs or by activating various Src family kinases required for the antigen receptor signaling and it also can suppress JAK kinases.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans