Human CellExp™ CD46, Human Recombinant

Biomolecule/Target: N/A

Synonyms: CD46, AHUS2, MCP, MIC10, TLX, TRA2.10

Alternates names: CD46, AHUS2, MCP, MIC10, TLX, TRA2.10

Taglines: Has cofactor activity for inactivation of complement components C3b and C4b by serum factor I.

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 4179

NCBI Gene Symbol: CD46

Gene Source: Human

Accession #: P15529

Recombinant: True

Source: HEK 293 cells

Purity by SDS-PAGE #: >90%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 33.6 kDa. The protein migrates as 45-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

Background Information: Complement regulatory protein CD46 is also known as membrane Cofactor Protein (MCP), is a type I membrane protein and is a regulatory part of the complement system. CD46 is expressed by all cells except erythrocytes. MCP acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue, and also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2).

Amino acid sequence: AA Cys 35 - Asp 328

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans