Human CellExp™ CEACAM1/CD66a, Extracellular Domain (ED), Human Recombinant

Biomolecule/Target: CEACAM1

Synonyms: Carcinoembryonic antigen-related cell adhesion molecule 1, BGP, BGP1, BGPI, CD66a, CEACAM‑1, CEACAM1, CEAM1

Alternates names: Carcinoembryonic antigen-related cell adhesion molecule 1, BGP, BGP1, BGPI, CD66a, CEACAM‑1, CEACAM1, CEAM1

Taglines: Cell adhesion protein that plays role in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 634

NCBI Gene Symbol: CEACAM1

Gene Source: Human

Accession #: P13688

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGE #: ≥95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): Measured by its binding ability in a functional ELISA.

Biological activity: Immobilized Human TIM3 at 5 μg/ml (100 μl/well) can bind to biotinylated CEACAM1 (ED) with a linear range of 0.08-10 µg/ml.

Results: N/A

Binding Capacity: Immobilized Human TIM3 at 5 μg/ml (100 μl/well) can bind to biotinylated CEACAM1 (ED) with a linear range of 0.08-10 µg/ml.

Unit Definition: N/A

Molecular Weight: 45 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 μm filtered solution in PBS pH 7.4

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in distilled water.

Background Information: CEACAM1, also known as biliary glycoprotein I (BGP I) or CD66a, is an extensively studied cell surface molecule with established functions in multiple cancer types, as well as in various compartments of the immune system. The highly glycosylated CEACAM1 contains a 35-428 amino acid extracellular domain (ECD) which includes one N-terminal V-type Ig-like domain, followed by three C2-type Ig-like domains. CEACAM1 is a surface glycoprotein expressed on various blood cells, epithelial cells, and vascular cells. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic binding, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans