Human CellExp™ Complement C5a , Mouse recombinant

Biomolecule/Target: N/A

Synonyms: C5a, Complement Component 5a, Hemolytic complement

Alternates names: C5a, Complement Component 5a, Hemolytic complement

Taglines: a potent chemotactic factor for human peripheral blood neutrophils and monocytes

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 15139

NCBI Gene Symbol: C5

Gene Source: Mouse

Accession #: P06684

Recombinant: True

Source: E.coli

Purity by SDS-PAGE #: >95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 10.9 kDa. The protein migrates as 14 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized powder

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

Background Information: Complement Component C5a (C5a) is also known as C5,and is a protein fragment released from complement component C5, is a potent chemotactic factor for human peripheral blood neutrophils and monocytes, and is believed to play an important role in a number of inflammatory conditions. There are several functions in the below: C5a is an anaphylatoxin, causing the release of histamine from mast cells; C5a is effective leukocyte chemoattractants, causing the accumulation of white blood cells, especially neutrophil granulocytes, at sites of complement activation; C5a activates white blood cells by increasing avidity for white blood cell integrins and upregulating the Lipoxygenase pathway for arachidonic acid metabolism; C5a is a powerful inflammatory mediator, and seems to be a key factor in the development of pathology of many inflammatory diseases involving the complement system; C5a modulates balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing autoimmune response.

Amino acid sequence: AA Asn 679 - Arg 755

Handling: Centrifuge the vial prior to opening.

Usage: N/A